1-Bromo-4-fluorobenzene → HCID 89586304, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 3-(1-phenyl-1H-pyrazol-5-yl)-1-piperidin-4-ylpyridazin-4(1H)-one (0.30 g), 1-bromo-4-fluorobenzene (0.21 mL), Pd2(dba)3 (43 mg), X-phos (45 mg) and sodium tert-butoxide (135 mg) in toluene (10 mL) was stirred at 120° C. for 5 hr under an argon atmosphere. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) and recrystallized from ethyl acetate/hexane to give the title compound (0.32 g).

Provenance & Evidence