Dimethylbarbituric acid → HCID 68014880, compound

Participants

Reaction Steps

A suspension of 3-(1-phenyl-1H-pyrazol-5-yl)-1-(1-prop-2-en-1-yl-1,2,3,6-tetrahydropyridin-4-yl)pyridazin-4(1H)-one (0.10 g), tetrakis(triphenylphosphine)palladium(0) (50 mg), 1,3-dimethylbarbituric acid (0.13 g) and dichloromethane (5 mL) was heated under reflux for 2 hr under a nitrogen atmosphere, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate) and recrystallized from 2-propanol/ethyl acetate to give the title compound (32 mg).

Provenance & Evidence