Sodium hydride → HCID 68014853, compound

Participants

Reaction Steps

5-Methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol (0.0478 g) was dissolved in DMF (3.6 mL), NaH (0.0078 g, 60%, in oil) and tetrabutylammoniumiodide (0.0131 g) were added at 0° C., and the mixture was stirred at the same temperature for 20 min. To the reaction mixture was added 3-(bromomethyl)biphenyl (0.0462 g) at 0° C., and the mixture was stirred at room temperature for 2.5 days. The reaction mixture was diluted with water, extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, filtered, concentrated, and purified by silica gel column chromatography (ethyl acetate/hexane→methanol/ethyl acetate) to give the title compound (0.0385 g).

Provenance & Evidence