Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Chloro-3-(trifluoromethyl)pyridine | HCID 589833 | — |
| Reactant | 3-Hydroxyazetidine hydrochloride | HCID 2759290 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 60248807 | HCID 60248807 | 23.5% |
Reaction Steps
A suspension of azetidin-3-ol hydrochloride (500 mg), 2-chloro-3-(trifluoromethyl)pyridine (425 mg) and cesium carbonate (1.14 g) in DMF (5 ml) was stirred at 50° C. for 12 hr, and water was added. The reaction mixture was extracted with ethyl acetate, the extract was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (120 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09150588B2 |
|---|
| Source dataset | uspto-grants-2015_10 |
|---|
| ORD ID | ord-d7007b473b814c8e8b15186ac00748db |
|---|
| Source note | uspto-grants-2015_10 |
|---|
