Water → HCID 68014858, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol (200 mg), 1-(diphenylmethyl)azetidin-3-yl methanesulfonate (354 mg) and cesium carbonate (729 mg) in DMF (5 mL) was stirred at 100° C. for 12 hr, and water was added. The reaction mixture was extracted with ethyl acetate, the extract was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (35 mg).

Provenance & Evidence