反应详情

To a solution of 1-phenyl-5-(1-phenyl-1H-pyrazol-5-yl)penta-1,4-diyn-3-ol (0.50 g) in dichloromethane (20.0 mL) was added manganese dioxide (0.438 g), and the mixture was heated under reflux for 2 hr. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane) to give the title compound (0.310 g).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2 hr
3. filtrationThe reaction mixture was filtered
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (dichloromethane)