Sodium Sulfide → 2-phenyl-6-(1-phenyl-1H-pyrazol-5-yl)-4H-thiopyran-4-one

関与物質

反応手順

To sodium sulfide (0.079 g) was added 0.25 M sodium ethoxide in ethanol solution (20.0 mL), and the mixture was stirred at room temperature for 10 min. To a solution of 1-phenyl-5-(1-phenyl-1H-pyrazol-5-yl)penta-1,4-diyn-3-one (0.25 g) in ethanol (10.0 mL) was added the above-mentioned solution, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane/methanol) to give the title compound (80.0 mg).

情報源と証拠