Sodium Hydroxide → HCID 123920024, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of di-tert-butyl (1-phenyl-1H-pyrazol-5-yl)imidodicarbonate (5.30 g) in methanol (100 mL) was added 1N aqueous sodium hydroxide solution (73.0 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hr. The reaction mixture was concentrated and adjusted to pH 5-6 with 2N hydrochloric acid. The reaction mixture was extracted with dichloromethane, and the extract was washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (3.80 g).

Provenance & Evidence