Sodium Methoxide → HCID 89586553, compound

Participants

Reaction Steps

To a solution of 3,5-dichloro-1-(1-phenyl-1H-pyrazol-5-yl)pyrazin-2(1H)-one (0.627 g) in methanol (15.0 mL) was added sodium methoxide (0.132 g) at room temperature, and the mixture was stirred for 2 hr. The reaction mixture was concentrated and adjusted to pH 5-6 with 2N hydrochloric acid. The reaction mixture was extracted with dichloromethane. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane/methanol) to give the title compound (0.362 g).

Provenance & Evidence