Cesium carbonate → HCID 68014787, compound

Participants

Reaction Steps

To a mixture of 5-chloro-3-methoxy-1-(1-phenyl-1H-pyrazol-5-yl)pyrazin-2(1H)-one (245 mg), tri-tert-butylphosphine (25.0 mg), Pd2(dba)3 (37.0 mg), cesium carbonate (791 mg) and 1,4-dioxane (10.0 ml) was added phenylboronic acid (120 mg) at room temperature. The reaction mixture was heated using a microwave reactor at 95° C. for 1.5 hr. The reaction mixture was concentrated, dichloromethane was added, and the mixture was washed with saturated brine. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate) to give the title compound (18.0 mg).

Provenance & Evidence