Sulfuric Acid → HCID 86663613, compound
Reaction equation
[F:1][C:2]1([F:16])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]#[N:13])=[CH:11][C:5]=2[O:4][C:3]1([F:15])[F:14].S(=O)(=O)(O)[OH:18]>O>[F:16][C:2]1([F:1])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([NH2:13])=[O:18])=[CH:11][C:5]=2[O:4][C:3]1([F:14])[F:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 40 °C
Procedure
To 2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carbonitrile (200 mg) were added concentrated sulfuric acid (2 mL) and water (0.3 mL) at room temperature. The reaction mixture was stirred at 40° C. for 3 hr, water was added and the mixture was stirred for 40 min at room temperature. The resulting solid was collected by filtration, washed with purified water, and dried under reduced pressure to give the title compound (190.6 mg).
Workup
- stirringthe mixture was stirred for 40 min at room temperature
- filtrationThe resulting solid was collected by filtration
- washwashed with purified water
- customdried under reduced pressure
Sources & evidence
- ORD record
- ord-9f90c4b3013f405d84c49f06e735a90c
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09150591B2
Reaction notes
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