Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1747944생성일: 2026년 10월 25일
Potassium Carbonate → 9-[4-(Cycloheptyloxy)phenyl]-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide
https://huagongshe.com/reaction/1747944
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Bromocycloheptane | HCID 16992 | — |
| 반응물 | 4-(2,2-Dioxido-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)phenol | HCID 66747817 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 9-[4-(Cycloheptyloxy)phenyl]-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide | HCID 66748706 | 35.6% |
반응 단계
To a mixture of 4-(2,2-dioxido-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)phenol (300 mg), potassium carbonate (390 mg) in DMSO (5 mL) was added bromocycloheptane (250 mg). The mixture was stirred at 130° C. for 1 hr. Another bromocycloheptane (100 uL) was added and the mixture was stirred at room temperature overnight. 0.5 N NaOH aq., EtOAc and THF were added and the extracted organic layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was crystallized from MeCN/IPE to give the title compound (144 mg) as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09150591B2 |
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| 출처 데이터셋 | uspto-grants-2015_10 |
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| ORD ID | ord-7767368a879a4bb3a42fcedfabe657aa |
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| 출처 메모 | uspto-grants-2015_10 |
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