참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 3-Chloro-5-methylpyrazin-2-amine | HCID 15149676 | — |
| 반응물 | B-[6-(cyclohexyloxy)-3-pyridinyl]Boronic acid | HCID 66747855 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 3-[6-(Cyclohexyloxy)pyridin-3-yl]-5-methylpyrazin-2-amine | HCID 66748755 | 85.6% |
반응 단계
Tetrakis(triphenylphosphine)palladium(0) (48.3 mg) was added to a suspension of 3-chloro-5-methylpyrazin-2-amine (200 mg), 6-(cyclohexyloxy)pyridin-3-ylboronic acid (339 mg) and sodium carbonate (295 mg) in DME (5 mL) and water (1 mL) and the mixture was stirred at 90° C. under nitrogen for 3 hr. Water and EtOAc were added and the organic layer was separated, washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give the title compound (339 mg) as light brown gum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09150591B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_10 |
|---|
| ORD ID | ord-92f617b832044007b9481a34deb83711 |
|---|
| 출처 메모 | uspto-grants-2015_10 |
|---|
