HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → 1-(2-Aminopyridin-3-yl)-4-phenylcyclohexanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | Tert-butyl[3-(1-hydroxy-4-phenylcyclohexyl)pyridin-2-yl]carbamate | HCID 86690661 | — |
| Product | 1-(2-Aminopyridin-3-yl)-4-phenylcyclohexanol hydrochloride | HCID 66748387 | — |
Reaction Steps
4N HCl-EtOAc (5 mL) was added to tert-butyl [3-(1-hydroxy-4-phenylcyclohexyl)pyridin-2-yl]carbamate (450 mg) and the mixture was stirred at room temperature overnight. The resulted precipitates were collected and dried in vacuo to give 1-(2-aminopyridin-3-yl)-4-phenylcyclohexanol hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150591B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-76d20945077946679a5629506d6268f0 |
| Source note | uspto-grants-2015_10 |