Ethanol → 1,1-Dimethylethyl (3-hydroxy-8-azaspiro[4.5]dec-2-yl)carbamate

HRID 174811Notes

Reaction equation

HRID 174811 reaction equation
[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][C:11]2([CH2:12][CH:13]1[OH:14])[CH2:15][CH2:16][N:17]([C:20]([O:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)=[O:29])[CH2:18][CH2:19]2.[CH3:30][CH2:31][OH:32].[OH-:33].[OH-:34].[Pd+2:35]>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][C:11]2([CH2:12][CH:13]1[OH:14])[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2

Participants

5

Reactant 4

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 69054060Phenylmethyl 2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-hydroxy-8-azaspiro[4.5]decane-8-carboxylate

Product 1

HCID 765808691,1-Dimethylethyl (3-hydroxy-8-azaspiro[4.5]dec-2-yl)carbamate

Sources & evidence

ORD record
ord-124ce976bb2d48b6807d18905a8da43c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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