Water → 5-Methyl-3-(3-phenoxyazetidin-1-yl)pyrazin-2-amine

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-Amino-3-bromo-5-methylpyrazine	HCID 9899043	—
Reactant	3-Phenoxyazetidine	HCID 12812501	—
Solvent	Dimethylformamide	HCID 6228	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	5-Methyl-3-(3-phenoxyazetidin-1-yl)pyrazin-2-amine	HCID 68280934	35.2%

Reaction Conditions

Temperature	120 °C

Reaction Steps

Potassium carbonate (18.53 mg) was added to a mixture of 3-phenoxyazetidine (20 mg) and 3-bromo-5-methylpyrazin-2-amine (25 mg) in DMF (dry) (1 mL). The mixture was stirred at 120° C. for 4 hr. Water and EtOAc were added and the extracted organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give the title compound (12 mg) as white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09150591B2
Source dataset	uspto-grants-2015_10
ORD ID	ord-f302c14cf79b40148ff48ec088e7df41
Source note	uspto-grants-2015_10