Chlorosuccinimide → HCID 86704400, compound

Participants

Reaction Steps

To a solution of the crude trans-2-phenylcyclopropanecarbaldehyde oxime rac-I-6C (04 g, 2.51 mmol) in DMF (5 mL) and cooled at 0°C. N-chlorosuccinimide (0.37 g, 2.7 mmol) was added portionwise. The reaction mixture was slowly warmed to rt and stirred fo(14 h. The reaction was quenched with saturated NaCl (aq.) and extracted with Et2O. The organics were collected, washed with water, brine, dried over Na2SO4, filtered, and concentrated under vacuum. The crude was purified by column chromatography on silica gel with hexane-EtOAc (5 to 20% gradient as eluant) to yield trans-N-hydroxy-2-phenylcyclopropanecarbimidoyl chloride.

Provenance & Evidence