(((2-Methylenecyclohexyl)methoxy)methyl)benzene → 4-((Benzyloxy)methyl)spiro[2.5]octane

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Reaction Steps

This intermediate was prepared from (((2-methylenecyclohexyl)methoxy)methyl)benzene by using the same protocol as described for ethyl spiro[2.5]octane-6-carboxylate (I-7A). 1H NMR (400 MHz, CDCl3) δ 7.35-7.31 (m, 4H), 7.29 (m, 1H) 4.49 (q, J=12.4 Hz, 2H), 3.52 (t, J=9.2 Hz, 1H), 3.41 (dd, J=9.2, 5.2 Hz, 1H), 1.72-1.67 (m, 1H), 1.49-1.43 (m, 4H), 1.33-1.26 (m, 1H), 0.88-0.85 (m, 1H), 0.37-0.31 (m, 2H), 0.19-0.14 (m, 2H). MS m/z 231.1 (M+1).

Provenance & Evidence