3-Cyclopropyl-3-Oxopropionic Acid Methyl Ester → HCID 67983906, compound

HRID 1748181Notes

Reaction equation

HRID 1748181 reaction equation
[OH:1][N:2]=[C:3](Cl)[CH:4]1[CH2:10][CH2:9][CH:8]2[CH:6]([CH2:7]2)[CH2:5]1.[CH:12]1([C:15](=O)[CH2:16][C:17]([O:19]C)=[O:18])[CH2:14][CH2:13]1>>[CH:6]12[CH2:7][CH:8]1[CH2:9][CH2:10][CH:4]([C:3]1[C:16]([C:17]([OH:19])=[O:18])=[C:15]([CH:12]3[CH2:14][CH2:13]3)[O:1][N:2]=1)[CH2:5]2

Participants

3

Reactant 2

HCID 101300163-Cyclopropyl-3-Oxopropionic Acid Methyl EsterHCID 86704407HCID 86704407, compound

Product 1

HCID 67983906HCID 67983906, compound

Procedure

3-(Bicyclo[4.1.0]heptan-3-yl)-5-cyclopropylisoxazole-4-carboxylic acid (I-12F) was prepared from N-hydroxybicyclo[4.1.0]heptane-3-carbimidoyl chloride and methyl 3-cyclopropyl-3-oxopropanoate following the same protocol as described for I-6E. MS m/z 248.1 (M+1).

Sources & evidence

ORD record
ord-431cce56764541a197f7e599b6af41ca
Source dataset
uspto-grants-2015_10
Patent number
US09150568B2

Reaction notes

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