Ethyl 2-chloro-1,3-benzothiazole-6-carboxylate → Ethyl 2-(3-((5-cyclopropyl-3-(2-phenylcyclopropyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]thiazole-6-carboxylate

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Ethyl 2-(3-((5-cyclopropyl-3-(2-phenylcyclopropyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]thiazole-6-carboxylate (10A) was prepared from tert-butyl 3-((5-cyclopropyl-3-(2-phenylcyclopropyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate and ethyl 2-chlorobenzothiazole-6-carboxylate following the procedure described in the preparation of Example 7. The crude product was purified by silica gel column chromatography with hexane-EtOAc 20% isocratic as eluant to yield the title compound.

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