Glycine methyl ester hydrochloride → HCID 67982976, compound

Participants

Reaction Steps

2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]thiazole-6-carboxylic acid (34 mg, 0.06 mmol) was combined with glycine methyl ester hydrochloride (8 mg, 0.06 mmol), O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (25 mg, 0.065 mmol), diisopropylethylacetate (0.05 ml) and dichloromethane (2 mL). The mixture was stirred for 1 hour, then the solvent was removed in vacuo. The residue was suspended in ethyl acetate (15 mL) and washed with sodium bicarbonate solution (5 mL). The organics were combined and dried (MgSO4) then evaporated in vacuo. The product was purified by flash silica chromatography with 0-100% ethyl acetate in hexanes and used directly in the next procedure.

Provenance & Evidence