3,4-Difluorobenzonitrile → HCID 67982995, compound

HRID 1748218Notes

Reaction equation

HRID 1748218 reaction equation
[CH:1]12[NH:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][CH:3]([O:9][CH2:10][C:11]1[C:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:25][CH:26]([F:28])[F:27])=[N:13][O:14][C:15]=1[CH:16]1[CH2:18][CH2:17]1)[CH2:2]2.[F:29][C:30]1[CH:31]=[C:32]([CH:35]=[CH:36][C:37]=1F)[C:33]#[N:34]>>[CH:16]1([C:15]2[O:14][N:13]=[C:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:25][CH:26]([F:27])[F:28])[C:11]=2[CH2:10][O:9][CH:3]2[CH2:2][CH:1]3[N:8]([C:37]4[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[CH:31][C:30]=4[F:29])[CH:5]([CH2:6][CH2:7]3)[CH2:4]2)[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 5872033,4-DifluorobenzonitrileHCID 67983865HCID 67983865, compound

Product 1

HCID 67982995HCID 67982995, compound

Procedure

4-(3-((5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-3-fluorobenzonitrile (26-A) was prepared from 4-((8-azabicyclo[3.2.1]octan-3-yloxy)methyl)-5-cyclopropyl-3-(2-(difluoromethoxy)phenyl)isoxazole and 3,4-difluorobenzonitrile according to the procedure described for the preparation of example 23.

Workup

  1. customdescribed for the preparation of example 23

Sources & evidence

ORD record
ord-e8846e7415dd45ab9b8ece7d18b39442
Source dataset
uspto-grants-2015_10
Patent number
US09150568B2

Reaction notes

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