反应详情

温度

50 °C

A mixture of diethyl 1-(2-cyanopropan-2-yl)-1H-indole-2,6-dicarboxylate (9.3 g, 23.3 mmol) and Raney Ni (4 g of 50% wet catalyst) and water (5 mL) water is heated to 50° C. under 250 psi of H2. The mixture is stirred for 18 h. LCMS shows complete reaction with high purity. The mixture is filtered through Celite, keeping the catalyst wet until properly disposed. The solvent was removed under reduced pressure to afford the title compound (7.7 g, 95%) as a white solid.

1. customreaction with high purity
2. filtrationThe mixture is filtered through Celite
3. customThe solvent was removed under reduced pressure