Hydrochloric Acid → HCID 67235277, compound

Participants

Reaction Steps

To a solution of (5R)-5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylate (3.65 g, crude) in ethanol (30 mL) is added 1M NaOH solution (13.8 mL, 13.8 mmol). The reaction mixture is refluxed for 2 h. The reaction mixture is acidified with 1M HCl and ethanol is removed under vacuum. The resulting solid is collected by filtration, is washed with water and dried to afford the title compound (2.1 g, 41% for 3 steps) as a solid.

Provenance & Evidence