HCID 67235600, compound → HCID 67235223, compound

HRID 1748287Notes

Reaction equation

HRID 1748287 reaction equation
[CH3:1][C@H:2]1[C@H:18]([CH3:19])[N:7]2[C:8]3[CH:9]=[C:10]([C:15]([OH:17])=[O:16])[CH:11]=[CH:12][C:13]=3[CH:14]=[C:6]2[C:5](=[O:20])[NH:4][CH2:3]1.C[C@H]1[C@H](C)OS(=O)(=O)N(C(OC(C)(C)C)=O)C1>>[CH3:1][C@H:2]1[C@@H:18]([CH3:19])[N:7]2[C:8]3[CH:9]=[C:10]([C:15]([OH:17])=[O:16])[CH:11]=[CH:12][C:13]=3[CH:14]=[C:6]2[C:5](=[O:20])[NH:4][CH2:3]1

Participants

3

Reactant 2

HCID 67235600HCID 67235600, compound2×HCID 86682392HCID 86682392, compound

Product 1

HCID 67235223HCID 67235223, compound

Procedure

This compound is synthesized using the similar procedure used to prepare trans-4,5-dimethyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylic acid (Intermediate O), replacing the tert-butyl cis-5,6-dimethyl-1,2,3-oxathiazinane-3-carboxylate 2,2-dioxide with tert-butyl trans-5,6-dimethyl-1,2,3-oxathiazinane-3-carboxylate 2,2-dioxide in step 6.

Workup

  1. customThis compound is synthesized

Sources & evidence

ORD record
ord-551699966fd24a3e94abeedf01e730f1
Source dataset
uspto-grants-2015_10
Patent number
US09150577B2

Reaction notes

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