diethyl 1-(3-azido-2,2-difluoropropyl)-1H-indole-2,6-dicarboxylate → diethyl 1-(3-amino-2,2-difluoropropyl)-1H-indole-2,6-dicarboxylate

Participants

Reaction Steps

To a solution of diethyl 1-(3-azido-2,2-difluoropropyl)-1H-indole-2,6-dicarboxylate (2.5 g, 7.8 mmol) in methanol:CH2Cl2 (1:1, 60 mL) is added 10% palladium on carbon (1.4 g, 1.3 mmol). The reaction mixture is stirred for 3.5 h under H2 atmosphere. The reaction mixture is filtered and the filtrate is concentrated to afford the title crude compound (2.3 g) which is used in the next step without purification.

Provenance & Evidence