Acetic Acid → HCID 67235206, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of ethyl 1-oxo-2,2′,3,3′,5′,6′-hexahydro-1H-spiro[1,4-diazepino[1,2-a]indole-4,4′-pyran]-8-carboxylate (4.2 g, 12.2 mmol) in ethanol (120 mL) is added NaOH (1.22 g, 30.5 mmol) and water (30 mL). The reaction mixture is heated at 80° C. for 2 h. Acetic acid (19 mL) and water (180 mL) are added and the resulting solid is collected by filtration, washed with water and dried to afford the title compound (2.42 g, 64%) as a white solid.

Provenance & Evidence