4-Hydroxymethylpyridine → HCID 67235215, compound

Participants

Reaction Steps

To a stirred solution of 4-nitro-1H-pyrazole (211 mg, 1.87 mmol), pyridine-4-methanol (0.28 mL, 2.56 mmol), and triphenylphosphine (538 mg, 2.05 mmol) in THF (10 mL) under nitrogen is added di-t-butyl azodicarboxylate (472 mg, 2.05 mmol) over 3 min. The reaction mixture was stirred for 16 h at room temperature. The mixture is concentrated and is purified by flash column chromatography using a gradient of 0-3% methanol in CH2Cl2 to afford the title compound as a yellow oil (247 mg, 65%).

Provenance & Evidence