Hydrazine hydrate (1:1) → 5-Tert-butyl-1,3-oxazole-2-carbohydrazide

Participants

Reaction Conditions

Reaction Steps

To a mixture of ethyl 5-tert-butyl-1,3-oxazole-2-carboxylate (28 g, 142 mmol) in ethanol (200 mL) is added hydrazine hydrate (7.1 g, 142 mmol). The reaction mixture is heated at 85° C. for 3 h. The solvent is evaporated and the residue is washed with n-pentane to afford the title compound (25 g, 96%) as a white solid.

Provenance & Evidence