Sodium Hydroxide → HCID 67235137, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[4-chloro-2-(morpholin-4-ylmethyl)-6-nitrophenyl]-2,2,2-trifluoroacetamide (3.6 g, 9.6 mmol) in ethanol (60 mL) is added a 10% aqueous NaOH solution (60 mL, 150 mmol) and the reaction is heated to 80° C. for 3 h. The mixture is cooled to room temperature and is stirred an additional 16 h. Most of the ethanol is evaporated under reduced pressure and the resulting solid is isolated by filtration to afford the title compound (2 g, 77%).

Provenance & Evidence