Sodium Hydroxide → HCID 86692407, compound

HRID 1748434Notes

Reaction equation

HRID 1748434 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:9]=[N:10][N:11]([C:14]2[C:19]([Cl:20])=[CH:18][C:17]([Cl:21])=[CH:16][N:15]=2)[C:12]=1[CH3:13])=[O:7])C>O>[Cl:20][C:19]1[C:14]([N:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[N:10]2)=[N:15][CH:16]=[C:17]([Cl:21])[CH:18]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86692406HCID 86692406, compound

Product 1

HCID 86692407HCID 86692407, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

4N Aqueous solution of sodium hydroxide (10 ml) and water (10 ml) were added to 1-(3,5-dichloropyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (1.0 g) and stirred at 80° C. for 2.5 hours. The reaction solution was washed with ethyl acetate and 1N hydrochloric acid aqueous solution was added to the aqueous layer at 0° C. The precipitated solid was collected by filtration and washed with water to give the titled compound (680 mg) as a white solid.

Workup

  1. washThe reaction solution was washed with ethyl acetate and 1N hydrochloric acid aqueous solution
  2. additionwas added to the aqueous layer at 0° C
  3. filtrationThe precipitated solid was collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-7aed851a8a1d44e69359e1f7ec3d9fe5
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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