Hydrochloric Acid → HCID 86692446, compound

Participants

Reaction Conditions

Reaction Steps

1N Aqueous solution of sodium hydroxide (16 ml) was added at room temperature to a solution of 5-cyclopropyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester (802 mg) in ethanol (16 ml) and stirred at 70° C. for 12 hours. After completion of the reaction, the reaction solution was cooled to room temperature and 1N hydrochloric acid aqueous solution was added until the solution became pH 1-2. The precipitated solid was collected by filtration to give the titled compound (615 mg) as a brown solid.

Provenance & Evidence