反应详情

Next, 1-(4-methoxyphenyl)pyrrole-3-carbaldehyde was added to an aqueous solution (100 ml) of sodium hydroxide (4.38 g) and an aqueous pyridine solution (water 100 ml and pyridine 180 ml) of potassium permanganate (8.65 g) at 20-30° C., and stirred at room temperature for six hours. After completion of the reaction, the reaction solution was filtered through Celite, the filtrate was acidified by the addition of hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, concentrated in vacuo and the precipitated solid was purified with ethyl acetate/n-hexane to give the titled compound (8.52 g).

1. customAfter completion of the reaction
2. filtrationthe reaction solution was filtered through Celite
3. additionthe filtrate was acidified by the addition of hydrochloric acid
4. extractionextracted with ethyl acetate
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. concentrationconcentrated in vacuo
7. customthe precipitated solid was purified with ethyl acetate/n-hexane