反应详情

4-Fluoroaniline (117 g) and 2,5-dimethoxytetrahydrofuran (139 g) were added to acetic acid (120 ml), stirred at reflux temperature for an hour and then the reaction solution was poured into ice water (1 l). The precipitated solid was filtered, dissolved in methanol and water was added therein. The precipitated solid was collected again by filtration to give 1-(4-fluorophenyl)pyrrole (122.7 g).

1. temperatureat reflux temperature for an hour
2. filtrationThe precipitated solid was filtered
3. dissolutiondissolved in methanol
4. additionwater was added
5. filtrationThe precipitated solid was collected again by filtration