Potassium Carbonate → HCID 43542552, compound

Participants

Reaction Steps

A solution of 1H-pyrazole-4-carboxylic acid ethyl ester (1.65 g), 5-iodo-m-xylene (1.65 g), copper (I) iodide (68 mg), N,N′-dimethyl-1,2-cyclohexanediamine (222 mg) and potassium carbonate (2.06 g) in toluene (2 ml) was stirred at 110° C. for 48 hours. After completion of the reaction, water was added and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was dissolved in ethanol (10 ml), 1N aqueous solution of sodium hydroxide (10 ml) was added and the mixture was stirred at room temperature overnight. The reaction solution was concentrated by an evaporator, the aqueous solution was acidified by the addition of 1N hydrochloric acid aqueous solution and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated to give the titled compound (438 mg) as a dark brown solid.

Provenance & Evidence