1-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid → 5-Methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylic acid

Participants

Reaction Steps

To a solution of 1-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid (30 mg) described in Reference Example 24 in N,N-dimethylformamide (1 ml) was added 10% palladium carbon (containing about 50% water) (10 mg) at room temperature, and stirred at the same temperature for 30 minutes under hydrogen atmosphere. After completion of the reaction, the reaction solution was filtered through Celite, then the solvent was evaporated in vacuo, azeotropically concentrated together with toluene to give the titled compound (23 mg) as a white solid.

Provenance & Evidence