HCID 86692552, compound → HCID 86692551, compound

Participants

Reaction Steps

To a solution of 5-methyl-1-(4-methyl-5-nitropyridin-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester (22.3 g) in ethanol (600 ml) and acetic acid (50 ml) was added palladium carbon (1.0 g), and stirred at room temperature for 6 hours under hydrogen atmosphere (1 atm). After completion of the reaction, the mixture was filtered through Celite, then the filtrate was concentrated, and the obtained residue was dissolved in chloroform. The organic layer was washed with saturated sodium bicarbonate water and water sequentially, dried over anhydrous sodium sulfate, and then the solvent was evaporated. To the obtained residue was added a small amount of diethyl ether and n-hexane, the precipitated solid was collected by filtration, and heat-dried in vacuo at 60° C. to give 1-(5-amino-4-methylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (18.3 g) as a pale yellow solid.

Provenance & Evidence