Sodium Hydroxide → HCID 86692555, compound

Participants

Reaction Conditions

Reaction Steps

5-Methyl-1-[4-methyl-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (270 mg) was dissolved in tetrahydrofuran (5 ml), 1 N aqueous solution of sodium hydroxide (5 ml) was added thereto, and stirred at 80° C. for 4 hours. After completion of the reaction, the solvent was evaporated, to the aqueous layer was added concentrated hydrochloric acid under ice-cooling to adjust the layer to pH 5, the precipitated solid was collected by filtration, and dried at 60° C. under air blow to give the titled compound (204 mg) as a white solid.

Provenance & Evidence