Hexane → HCID 178469886, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-hydroxy-4-(trifluoromethyl)benzamidine (3.0 g) in ethanol (30 ml) was added ethyl acetylenecarboxylate (1.44 g), and stirred at 80° C. for 26 hours. After the solvent was evaporated, diphenylether (15 ml) was added thereto, and additionally stirred at 180° C. for 5.5 hours. After completion of the reaction, the mixture was allowed to cool to room temperature, and n-hexane was added thereto. The insoluble matter was collected by filtration, washed with n-hexane, and then dried to give 2-[4-(trifluoromethyl)phenyl]-1H-imidazole-4-carboxylic acid ethyl ester (1.84 g).

Provenance & Evidence