Sodium Hydroxide → HCID 13823606, compound

Participants

Reaction Steps

To a solution of 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (5.83 g) in tetrahydrofuran (20 ml) and methanol (20 ml) was added 4 N aqueous solution of sodium hydroxide (30 ml), and stirred at room temperature. After completion of the reaction, the solvent was evaporated, to the aqueous layer was added concentrated hydrochloric acid under ice-cooling to adjust the layer to pH 5, the precipitated solid was collected by filtration, and dried at 60° C. under air blow to give the titled compound (4.89 g) as a white solid. MS (ESI) m/z: 339, 341 (M+H)+.

Provenance & Evidence