Water → HCID 178429260, compound

Participants

Reaction Steps

A solution of 1-(4-tert-butylphenyl)-5-methyl-N-[6-(4-oxocyclohexyl)pyridin-3-yl]-1H-pyrazole-4-carboxamide (136 mg) in ethanol (5 ml) was cooled in ice water, sodium borohydride (48 mg) was added and stirred at the same temperature for an hour. After the reaction, water was added and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified with a silica gel column chromatography (n-hexane/ethyl acetate), washed with ethanol, the resulting solid was filtered and dried at 60° C. in vacuo to give the titled compound (29 mg) as a white solid.

Provenance & Evidence