HCID 86692578, compound → HCID 178428628, compound

HRID 1748649Notes

Reaction equation

HRID 1748649 reaction equation
[Cl:1][C:2]1[C:3]([N:12]2[C:16]([CH3:17])=[C:15]([C:18]([NH:20][C:21]3[CH:22]=[N:23][C:24]([CH:28]4[CH2:33][CH2:32][C:31](=[O:34])[CH2:30][CH2:29]4)=[C:25]([CH3:27])[CH:26]=3)=[O:19])[CH:14]=[N:13]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.FC1C(N2C(C)=C(C(NC3C=NC(C4CCC(=O)CC4)=C(C)C=3)=O)C=N2)=NC=C(C(F)(F)F)C=1>>[Cl:1][C:2]1[C:3]([N:12]2[C:16]([CH3:17])=[C:15]([C:18]([NH:20][C:21]3[CH:22]=[N:23][C:24]([C@H:28]4[CH2:29][CH2:30][C@H:31]([OH:34])[CH2:32][CH2:33]4)=[C:25]([CH3:27])[CH:26]=3)=[O:19])[CH:14]=[N:13]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

Participants

3

Reactant 2

HCID 86692578HCID 86692578, compoundHCID 86692588HCID 86692588, compound

Product 1

HCID 178428628HCID 178428628, compoundYield 30.6%

Procedure

1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-N-[5-methyl-6-(4-oxocyclohexan-1-yl)pyridin-3-yl]-1H-pyrazole-4-carboxamide (234 mg) described in Example F36 was used in place of 1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-N-[5-methyl-6-(4-oxocyclohexan-1-yl)pyridin-3-yl]-1H-pyrazole-4-carboxamide in Example 29, and reacted and treated in a similar manner to give the titled compound (72 mg) as a white solid.

Workup

  1. customreacted
  2. additiontreated in a similar manner

Sources & evidence

ORD record
ord-578750c35d194a38817aca351ce91a42
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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