Hydrochloric Acid → HCID 86692589, compound

Participants

Reaction Steps

1N Aqueous solution of sodium hydroxide (20 ml) was added to a suspension of N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3-carboxamide (2.07 g) in methanol (20 ml) and tetrahydrofuran (30 ml), and stirred at room temperature for 2.5 hours. 1N Hydrochloric acid aqueous solution was added at 0° C. to the reaction solution and concentrated in vacuo. The precipitated solid was washed with ethanol to give N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-1H-pyrrole-3-carboxamide (1.2 g) as a white solid.

Provenance & Evidence