Tetrabutylammonium Fluoride → HCID 178428626, compound

Participants

Reaction Conditions

Reaction Steps

1M solution of tetra-n-butylammonium fluoride in tetrahydrofuran (0.2 ml) was added to trans-N-[6-(4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-5-methylpyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (41 mg) and stirred at 85° C. for six hours. After the reaction, the solvent was evaporated and the resulting residue was purified with a silica gel column chromatography (chloroform/methanol). Ethanol was added to the purified product, the precipitated solid was washed with water and dried at 60° C. in vacuo to give the titled compound (29 mg) as a white solid.

Provenance & Evidence