Hydrochloric Acid → HCID 89736045, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-[6-(8-cyano-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-yl]-1-(4-isopropylphenyl)-1H-pyrazole-4-carboxamide (236 mg) in a mixture of acetic acid (5 ml), water (1 ml) and 1N hydrochloric acid aqueous solution (1 ml) was stirred at 100° C. for two hours. After completion of the reaction, a saturated aqueous solution of potassium carbonate was added and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was purified with column chromatography to give the titled compound (216 mg).

Provenance & Evidence