Trifluoroacetic acid → HCID 86692606, compound

Participants

Reaction Steps

Trifluoroacetic acid (5.0 ml) was added at room temperature to a solution of N-methyl-{4-[3-methyl-5-({5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carbonyl}-amino)pyridin-2-yl]cyclohex-3-en-1-yl}carbamoic acid carbamic acid tert-butyl ester (1.47 g) of Example D249 in dichloromethane (25 ml), and stirred at the same temperature for four hours. After completion of the reaction, 4N aqueous solution of sodium hydroxide (15 ml) was added and the solvent was evaporated. Ethanol (15 ml) and water were added to the resulting residue, stirred at room temperature for 30 minutes and the solid was filtered to give the titled compound (1.16 g) as a white solid.

Provenance & Evidence