Water → N-(6-chloro-5-cyanopyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

HRID 1748666노트

반응식

HRID 1748666 반응식
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:17](Cl)=[O:18].[NH2:20][C:21]1[CH:22]=[C:23]([C:28]#[N:29])[C:24]([Cl:27])=[N:25][CH:26]=1.O>N1C=CC=CC=1>[Cl:27][C:24]1[N:25]=[CH:26][C:21]([NH:20][C:17]([C:3]2[CH:4]=[N:5][N:6]([C:7]3[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][N:8]=3)[C:2]=2[CH3:1])=[O:18])=[CH:22][C:23]=1[C:28]#[N:29]

참가 물질

5

반응물 3

HCID 962WaterHCID 204962095-Amino-2-chloropyridine-3-carbonitrileHCID 897349975-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid chloride

생성물 1

HCID 86692611N-(6-chloro-5-cyanopyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide수율 195.8%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

5-Methyl-1-(5-(trifluoro methyl)pyridin-2-yl)-1H-pyrazole-4-carboxylic acid chloride (200 mg) and 5-amino-2-chloro-3-cyanopyridine (228 mg) were dissolved in pyridine (10 ml) and stirred at room temperature. After completion of the reaction, water was added to the reaction solution, the precipitated solid was collected by filtration and dried under heating and blow to give N-(6-chloro-5-cyanopyridin-3-yl)-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (550 mg) as a light brown solid.

후처리

  1. additionwas added to the reaction solution
  2. filtrationthe precipitated solid was collected by filtration
  3. customdried
  4. temperatureunder heating

출처 및 근거

ORD 기록
ord-79ace4301b51486bb49e09edddddf152
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150555B2

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