Water → N-{6-[1-Benzoyl-1,2,3,6-tetrahydropyridin-4-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

HRID 1748669Notes

Reaction equation

[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:10][C:11]1[N:15]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][N:17]=2)[N:14]=[CH:13][C:12]=1[C:26]([NH:28][C:29]1[CH:30]=[N:31][C:32]([C:36]2[CH2:37][CH2:38][NH:39][CH2:40][CH:41]=2)=[C:33]([CH3:35])[CH:34]=1)=[O:27].O>N1C=CC=CC=1>[C:1]([N:39]1[CH2:40][CH:41]=[C:36]([C:32]2[N:31]=[CH:30][C:29]([NH:28][C:26]([C:12]3[CH:13]=[N:14][N:15]([C:16]4[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][N:17]=4)[C:11]=3[CH3:10])=[O:27])=[CH:34][C:33]=2[CH3:35])[CH2:37][CH2:38]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 40 °C

Procedure

Benzoyl chloride (75 μl) was added to a solution of 5-methyl-N-[5-methyl-6-(1,2,3,6-tetrahydropyridin-4-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (221 mg) in pyridine (2.5 ml), and stirred at 40° C. for six hours. Water was added to the reaction solution, the precipitated solid was washed with ethanol and water to give the titled compound (218 mg) as a white solid.

Workup

washthe precipitated solid was washed with ethanol and water

Sources & evidence

ORD record: ord-9a0e4246fcb142fbb1cf0e88970c8d66
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09150555B2

Reaction notes

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