反应详情

N-{6-[1-Acetyl-1,2,3,6-tetrahydropyridin-4-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (180 mg) described in Example K39 was dissolved in 1,4-dioxane (2 ml) and ethanol (2 ml), 10% palladium-carbon (containing ca. 50% water; 90 mg) was added, and stirred at room temperature under hydrogen atmosphere for 8.5 hours, then ethanol (1 ml) was added and stirred at 40° C. for two days. The reaction solution was filtered through Celite, washed with chloroform and ethanol and the solvent was evaporated in vacuo. The precipitated solid was washed with ethyl acetate and ethanol to give the titled compound (98 mg) as a white solid.

1. stirringstirred at 40° C. for two days
2. filtrationThe reaction solution was filtered through Celite
3. washwashed with chloroform and ethanol
4. customthe solvent was evaporated in vacuo
5. washThe precipitated solid was washed with ethyl acetate and ethanol