N-{6-[1-Benzoyl-1,2,3,6-tetrahydropyridin-4-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide → N-[6-(1-Benzoylpiperidin-4-yl)-5-methylpyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide

Participants

Reaction Conditions

Reaction Steps

N-{6-[1-Benzoyl-1,2,3,6-tetrahydropyridin-4-yl]-5-methylpyridin-3-yl}-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (110 mg) described in Example K40 was dissolved in 1,4-dioxane (5 ml) and ethanol (5 ml), 10% palladium-carbon (containing ca. 50% water; 90 mg) was added, and stirred at 40° C. under hydrogen atmosphere for seven hours. The reaction solution was filtered through Celite, washed with chloroform and ethanol and the solvent was evaporated in vacuo. The resulting residue was purified with silica gel chromatography (chloroform/methanol) to give the titled compound (88 mg) as a white solid.

Provenance & Evidence